Directed evolution of artificial metalloenzymes for in vivo metathesis
نویسندگان
چکیده
منابع مشابه
5. Directed evolution of artificial metalloenzymes: bridging synthetic chemistry and biology
Directed evolution is a powerful algorithm for engineering proteins to have novel and useful properties. However, we do not yet fully understand the characteristics of an evolvable system. In this chapter, we present examples where directed evolution has been used to enhance the performance of metalloenzymes, focusing first on ‘classical’ cases such as improving enzyme stability or expanding th...
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ژورنال
عنوان ژورنال: Nature
سال: 2016
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature19114